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indicates the link between TMAO and inflammation, where TMAO induces NLRP3 inflammasome formation and causes other immune responses [108]

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178 Patients with obstructive sleep apnea syndrome (OSA) or nocturnal hypoxemia (NH), both of which are characterized by recurrent hypoxia, tend to develop circadian rhythm disorders due to enhanced HIF-1 gene expression mediated by hypoxia in OSA