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[DOI] [PMC free article] [PubMed] 379.Doehner, W

Two human T1DM studies suggest a potential link between T1DM pathogenesis and circulating mitochondrial-encoded peptides levels

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Moreover, a multicentric, double-blind, placebo-controlled, randomized trial that used the same methodology found that in patients who are suffering from stage I or II HNSCC and on radiation therapy while taking 400 IU of -tocopherol daily had a significantly higher incidence of subsequent primary malignancies (60/1000 person-years) compared to those on placebo (25/1000 person-years)

[30] reported that protective antioxidant genes such as glutathione peroxidase are downregulated during T2DM, and both glutathione s-transferases (GSTs) and glutathione-dependent enzymes are important in the regulation of pathophysiological alterations in numerous chronic diseases, especially T2DM [30]