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Future preclinical studies should focus on robust mevalonate pathway inhibition in chemoresistant AML

The current standard operating procedure by the European Center for the Validation of Alternative Methods (ECVAM) recommends the use of MTT reduction as parameter to make prediction on the skin irritancy of substances using EpiSkin TM test method, while IL-1 endpoint is regarded as a useful adjunct to MTT assay 48

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No study has compared a 4-week KLOW cycle with a 6-, 8-, 12-, or 16-week cycle

Steatosis recurrence was defined by the presence of steatosis on post-LT imaging, including transient elastography

D.SimsA.RossM.BettagJ.WilderA.NatropD.et al (2024)