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Cell Lines and Media The following engineered human foreskin fibroblasts were obtained from Robert Weinberg (Whitehead Institute): BJeH, BJeHLT, BJeLR, DRD

Its an autoimmune disease in which the immune system produces antibodies that attack the thyroid, causing fibrosis or scarring of the thyroid tissue ( Hashimotos disease is associated with a variety of symptoms, including weight gain, fatigue, hair loss, anemia, constipation, cold intolerance, joint pain, dry skin, mood changes, difficulty concentrating, and more ( In addition to medication, diet and lifestyle modification can help reduce thyroid damage and improve symptoms and overall quality of life in people with Hashimotos

Code availability All the codes used in this work are freely available and can be found in the corresponding references provided in Methods

Patients with a greater T-cell response had longer progression-free survival (PFS) than did those with a small T-cell response

Age-dependent TDP-43-mediated motor neuron degeneration requires GSK3, hat-trick, and xmas-2

Supplementary Materials The following supporting information can be downloaded at: Table S1: PRISMA checklist