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Nevertheless, the ongoing shift toward westernized diets enriched with refined carbohydrates and processed foods, significantly disrupts gut microbiome adaptations, increasing susceptibility to chronic diseases (152, 156)

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Westerink RH, Ewing AG

Oncotarget (2017) 8(17):29487500

Although rare, gallbladder cancer can be considered as a highly fatal complication of gallstones, since the tumour has a high grade of malignancy and diagnosis is often delayed, despite that it is an incidentaloma in 12% of cases during cholecystectomy [170, 171]

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