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In addition, nearly one third of the population is missing the genes that allow them to metabolize glutathione properly

642 Currently, MAK683 is in a phase I clinical trial for treating diffuse large B-cell lymphoma (NCT02900651)

doi: 10.3389/fimmu.2020.570920 114

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While there are other GSTs capable of this conjugation reaction (notably in the alpha class), these other isoforms are much less efficient and their production is not induced by the stress events which cause the formation of 4-HNE (such as exposure to hydrogen peroxide, ultraviolet light, heat shock, cancer drugs, etc.), as the production of the more specific two isoforms is

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