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WHO Technical Report Series (World Health Organization, 2009)

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In addition, several studies have evaluated optimal models for HCV treatment within harm reduction and opioid treatment programs.[10,38,39] One large study (HERO study) conducted in eight opioid treatment programs and 15 community health centers randomized 755 individuals to sofosbuvir-velpatasvir plus patient navigation or sofosbuvir-velpatasvir plus modified directly observed therapy (mDOT).[10] Although there was slightly higher adherence to sofosbuvir-velpatasvir in the mDOT arm, there was no difference in SVR12 rates, with 60% and 91% of patients in the mDOT arm and 62% and 93% of patients in the patient navigation arm achieving an SVR12 in the intention-to-treat analysis and per-protocol analysis, respectively.[10] Potential Reinfection with HCV among Persons who Inject Drugs Multiple studies have shown a significant risk of HCV reinfection in persons cured with HCV therapy

As a next step, we should spend more time looking at past wins and failures of philanthropic spending in tobacco control

He had learned that Sinatra (Julianne Nicholson) was making sinister power moves behind his back that resulted in the deaths of innocent people and a bombshell cover-up regarding the discovery that there are survivors out in the world beyond the parameters of Paradise