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Description

Neurons located in the dorsomedial parvocellular subdivision of the paraventricular nucleus of the hypothalamus release corticotropin-releasing factor (CRF) in the hypophyseal portal system in response to stressors, which binds to CRH receptor type 1 (CRHR1) in hypophysis and leads to adrenocorticotropic hormone secretion in the systemic circulation, culminating in glucocorticoids (GCs) release [cortisol in humans and corticosterone (CORT) in rodents]

Anti-depressive effects of Kai-Xin-San on lipid metabolism in depressed patients and CUMS rats using metabolomic analysis

Die Studie zeigt, dass es hierbei zu einer vernderten Aminosuresequenz in der Transmembranregion mit nachfolgend verminderter Anhaftung an der Zellmembran kommt