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Once inside the cell, metformins positive charge leads to its sequestration within the negatively charged mitochondrial matrix, where it can reach concentrations up to 1,000-fold higher than in the extracellular space ( The cardioprotective effects of metformin are both dose-dependent and tissue-specific (Table 2)

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Access this chapter Subscribe and save Buy Now Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others Suggested Reading Allaman I, Blanger M, Magistretti PJ