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This nuclear localization in elderly Leydig cells correlated with reduced expression of 3-HSD, a crucial enzyme for testosterone synthesis, suggesting a link between nuclear FOXO4 and age-related decline in testosterone production [2]

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Girard J

Studies examining long-term neuroplasticity, neuroprotection, or recovery from injury more frequently employ every-other-day or three-times-weekly schedules, recognizing that structural brain changes require time to develop and may benefit from pulsed rather than continuous stimulation