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[168] [169] In June 2025, the European Medicines Agency recommended that the product information for semaglutide medicines be updated to include non-arteritic anterior ischemic optic neuropathy (NAION) as a very rare side effect, [170] while the World Health Organization concluded that the risk management plan for semaglutide should be revised to include NAION as a potential risk

Beyond cognitive enhancement, VR could serve as a diagnostic and prognostic tool, allowing for the assessment of subtle impairments in spatial navigation, attention, and executive function, which are often the earliest markers of neurodegeneration (Brugada-Ramentol et al., 2022)

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Real-world safety reports have documented cases of syncope (fainting), chest discomfort, and palpitations in individuals taking both drugs, even at standard doses