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For growth in L-DOPA medium, cells were inoculated in chemically-defined L-DOPA medium containing 0.1% L-asparagine, 0.1% dextrose, 3mg ml -1 KH 2 PO 4 , 0.25 mg ml - 1 MgSO 4 7H 2 O, 1 g ml - 1 thiamine, 5 ng ml - 1 biotin, and 0.2 mg ml - 1 L-3,4-dihydroxyphenylalanine (L-DOPA

The respiratory chain Heme is crucial for mitochondrial respiration, aiding in both electron transfer and structural stability in complexes II, III, and IV (Fig

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Medial Prefrontal Cortex The Medial Prefrontal Cortex (mPFC) is involved with many cognitive functions and is comprised primarily of excitatory pyramidal neurons and a smaller population of inhibitory interneurons (Xu et al., 2019)

Pericytes also react to cytokines and triggers the release of proinflammatory molecules, which leads to BBB breakdown in vitro and induces activation of a proinflammatory state of astrocytes, endothelial cells, and microglia, the brains innate immune cell [31]