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More fat burned = glycogen spared = longer time to fatigue Especially beneficial for CrossFit, endurance athletes, and metabolic conditioning MOTS-c improves physical performance by regulating mitochondrial respiration and metabolic substrate use. Reynolds et al., Nature Communications Supports Anti-Aging and Stress Resistance Emerging research suggests that MOTSc acts like a mitochondrial stress hormone , improving longevity pathways similar to caloric restriction

Afterwards, excessive ROS would interfere with Ca 2+ homeostasis in cardiomyocytes, affecting multiple ion transporters responsible for myocardial electrical activity and bringing about diastolic and systolic dysfunction and arrhythmia

org/10.4103/0378-6323.179088 Teskey, G., Abrahem, R., Cao, R., Gyurjian, K., Islamoglu, H., Lucero, M., Martinez, A., Paredes, E., Salaiz, O., Robinson, B., & Venketaraman, V

In skeletal muscle, IGF-1 promotes repair through increased satellite cell activation and muscle fiber regeneration

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