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However, in diabetes, oxidative stress and chronic inflammation alter IRP activity, leading to iron metabolism dysregulation, iron overload, and increased ferroptosis ( 2.3 Role of oxidative stress in diabetic cardiomyopathy In DCM, the disruption of iron homeostasis and persistent oxidative stress are key drivers of ferroptosis (62)

Disrupted NMDA signaling has also been implicated in a wide range of neuropsychiatric disorders other than ASD, including ID, schizophrenia, Alzheimers disease, and other mood disorders [66], suggesting different roles of NMDARs in synaptic plasticity and excitotoxicity [67, 68]

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Gonzalez-Flores JN, Shetty SP, Dubey A, Copeland PR

Phenolic and tyrosyl ring iodothyronine deiodination and thyroid hormone concentrations in the human central nervous system