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Furthermore, cigarette smoke can activate the autophagy-dependent mechanism mediated by the deacetylase HDAC6, while causes the cilia proteins to be delivered to the lysosome for degradation or recycling, shortening the airway cilia ( in vitro to cause e-cadherin-mediated barrier function destruction of airway epithelial cells, leading to increased infection risk by viruses and bacteria that exacerbate COPD (Oldenburger et al., 2014)

We recognize that quantitative methods of evaluating airway remodeling must include the direction of the 2D cross-section relative to the longitudinal axis of the airway and realize that the airways position significantly influences the quantitative parameters analysed 104