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Human cystathionine beta-synthase is a target for sumoylation

Filippatos G, Anker SD, Pitt B, et al

Hyperhomocysteinemia can cause downregulation of CSE and CBS, thereby causing production of H 2 S is injury ( 2 S protection in ECs can cause endothelial dysfunction and damage, and gradually lead to HHcy-related vascular disease (96)