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Compared with RSL3alone, RSL3 combined with H/R increased the total iron, Fe 2+ , Fe 3+ , MDA and GSSG levels, while the total glutathione and GSH levels and the GSH/GSSG ratio decreased, suggesting that in the presence of H/R, cell ferroptosis was higher (Figure S2a)

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Mechanism of action and impact of thiol homeostasis on efficacy of an enzyme replacement therapy for classical homocystinuria

The subsequent rise in intracellular calcium levels and the possible activation of PKC are thought to result in the exocytosis of vesicles filled with growth hormones from these pituitary cells

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