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(2) The accumulation of significant quantities of crushed resin fines and suspended solids within the resin bed, which interfere with the settling process

However, high doses can increase the probability of unwanted side effects

Metals present on the particle surface, including Fe, Co, Cr, and V, undergo redox cycling, while Cd, Hg, and Ni, as well as Pb, deplete glutathione and protein-bound sulfhydryl groups, resulting in ROS production 17,18,19,20

The peptide reaches the tissues that need it most without requiring systemic distribution

Webb AJ, Patel N, Loukogeorgakis S, Okorie M, et al