Abbreviations 3'UTR: 3-untranslated region 5hmC: 5-hydroxymethylcytosine 5mC: 5-methylcytosine A2780: Ovarian cancer cell line A2780 ALDH1A3: Acetaldehyde dehydrogenase 1 family member A3 ANXA9: Annexin A9 ASOs: Antisense oligonucleotides ATG14: Autophagy-related gene 14 AUC: Area Under the Curve AURKA: Aurora Kinase A AZA: Azacitidine BCL2: B-cell lymphoma-2 BCL2L2: BCL2-like 2 BETi: BET inhibitors BIRC3: Baculoviral IAP repeat-containing 3 BIRC5: Baculoviral IAP repeat-containing 5 BV: Bevacizumab C/EBP: CCAAT/enhancer-binding protein CASC10: Cancer Susceptibility Candidate 10 CASR: Calcium-sensing receptor CBP: CREB-binding protein CCAT1: Colorectal Cancer Associated Transcript 1 CD44: Cluster of Differentiation 44 CDDP: Cisplatin ceRNA: competing endogenous RNAs CI: Confidence Interval CICs: Cancer-initiating cells CircRNA: circular RNAs CRNDE: Colorectal Neoplasia Differentially Expressed CSCs: Cancer stem cells CSF-1: Colony-stimulating factor 1 CSK: C-terminal Src kinase ctDNA: Circulating tumor DNA DDR: DNA damage response DDR1: Discoidin Domain Receptor 1 DDX3X: Dead-box helicase 3 X-linked DDX5: Dead-box helicase 5 DEC: Decitabine DLT: Dose-Limiting Toxicity DNMTs: DNA methyltransferases EMT: Epithelialmesenchymal transition ENG: Endoglin EOC: Epithelial ovarian cancer EVs: Extracellular vesicles EZH2: Enhancer of Zeste Homolog 2 FBXL10: F-Box and Leucine-Rich Repeat Protein 10 FBXO32: F-box protein 32 FOSL2: FOS-Like 2 FOXP1: Forkhead box protein 1 FZD7: Frizzled Class Receptor 7 GAS5: Growth arrest-specific 7 GC: Gemcitabine + Carboplatin GSH: Glutathione GSK3B: Glycogen synthase kinase 3 GST: Glutathione transferases GSTP1: Glutathione S-transferase P1 HAT: Histone acetyltransferase HDAC: Histone deacetylase HDACi: HDAC inhibitors HDMTs: Histone demethylases HGSC: High-grade serous ovarian cancer HMT: Histone methyltransferases HOTAIR: HOX Transcript Antisense Intergenic RNA HOTTIP: HOXA Transcript at the Distal Tip HR: Homologous recombination HRD: Homologous recombination deficiency HRK: Hazard Ratio IC: Half-maximal Inhibitory Concentration IGF2BP1: Insulin-like growth factor 2 mRNA-binding protein 1 IGROV1: Ovarian cancer cell line IGROV1 JAK2: Janus Kinase 2 JHDM2A: JmjC-domain-containing histone demethylase 2 A KDM3A: Lysine demethylase 3 A KLF4: Krppel-like factor 4 LncRNA: long non-coding RNAs LNP: Lipid Nanoparticles M6A: N6-methyladenosine MAFG: MAF BZIP Transcription Factor G MAL: Myelin and Lymphocyte protein MALAT1: Metastasis-Associated Lung Adenocarcinoma Transcript 1 MAPK: Mitogen-Activated Protein Kinase METTL3: Methyltransferase-like 3 MiRNA: microRNAs MMP3: Matrix Metalloproteinase 3 mTOR: Mammalian Target of Rapamycin NAV3: Neuron Navigator 3 NF-B: Nuclear Factor-Kappa B NRF2: Nuclear factor-erythroid 2-related factor 2 OC: Ovarian cancer ORR: Objective Response Rate OS: Overall Survival PARP: The Poly (ADP-ribose) polymerase PARPi: PARP inhibitors PAX9: Paired box gene 9 PDX: Patient-Derived Xenograft PFS: Progression-Free Survival PI3K: Phosphoinositide 3-Kinase PTEN: Phosphatase and tensin homolog deleted on chromosome 10 RAD51: RAD51 recombinase STAT3: Signal Transducer and Activator of Transcription 3 SKOV3: Ovarian cancer cell line SKOV3 SLC31A1: Solute Carrier Family 31 Member 1 SRSF1: Serine-Rich Splicing Factor 1 TGF-: Transforming Growth Factor Beta TMEM88: Transmembrane Protein 88 TMIGD2: Transmembrane and Immunoglobulin Domain Containing 2 TP: Toosendanin UCA1: Urothelial carcinoma-associated 1 Wnt/-catenin: Wnt/-catenin pathway XIAP: X-linked inhibitor of apoptosis protein YAP1: Yes-Associated Protein 1 YBX1: Y-box binding protein-1 YES1: YES proto-oncogene 1 YTHDF1: YTH N6-methyladenosine RNA Binding Protein 1 YTHDF2: YTH (YT521-B homology) domain 2 ZEB2: Zinc Finger E-Box Binding Homeobox 2 References Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al
In essence, Epithalon aids in the maintenance of telomeres, the protective caps at the ends of chromosomes that shorten as we age
Cross-Talk between the Complement and the Kinin System in Vascular Permeability Immunology Letters 140, 7-13 (2011) Kuklina, EM
Cryotherapy has demonstrated particular promise for rheumatoid arthritis patients
For consumers in the UK, these nutritional benefits align with public health goals
These layers progressively became more damaged toward the end of the 2 and 4 weeks (Figure 6, Figure 7)
