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doi: 10.1016/j.chom.2018.05.004 109 FarzaeiMHBahramsoltaniRAbdollahiMRahimiR

CMS does all of the following to determine the adjustment, if any, applied to the historical benchmark: (A) Computes the regional adjustment in accordance with 425.656 and the prior savings adjustment in accordance with 425.658

Multiple AOD 9604 research studies have confirmed this distinction, and it remains one of the primary reasons researchers originally pursued this fragment as a standalone therapeutic agent