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By testing stone pipes for nicotine residue, the researchers determined the Nez Perce were cultivating wild strains of tobacco 1,200 years ago in the warm, dry climate along the Snake River

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Alcaro S, Arcone R, Costa G, De Vita D, Iannone M, Ortuso F, Procopio A, Pasceri R, Rotiroti D, Scipione L