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While cigarettes are known to cause cancer, heart disease, and lung disease, the FDA said the thousands of other components in cigarette smoke rather than nicotine itself were to blame

PMCID: PMC3088407

Closed systems typically have higher nicotine content than open systems.[77] Thus, legislators could consider establishing a tiered system, where open refillable systems are taxed at a lower rate than closed systems, with different rates designed to equalize taxation and keep it neutral, not introduce unnecessary disparities

WHO guidance under Article 11 of the FCTC recommends large warnings, and many countries require rotating text or pictorial labels

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