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In another meta-analysis among teenagers from Europe and North America, e-cigarette use was associated with the initiation of tobacco cigarette smoking (OR = 4.1, 95% confidence interval, 95%CI of 3.05.48) 4

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Structural impact of chronic cigarette smoking: meta-analytic procedures To identify areas of convergent gray matter decreases across studies, we performed a coordinate-based meta-analysis using the revised version [44, 45] of the activation (in this application, Anatomic) likelihood estimation (ALE) algorithm [26, 46] as implemented in GingerALE v2.3.4 ( ALE is a voxel-wise approach for combining neuroimaging results across a collection of experiments/contrasts and thereby identifying locations of statistically significant spatial convergence