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Chemicals and other irritants found in smoke can seriously damage the delicate mucous membranes of the throat leading to persistent irritation and inflammation of the mucous membranes, especially during chronic smoking

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For instance, the anterior insular cortex can be considered a key node of the salience network (SN), and neuroimaging studies have shown that the anterior insula modulates the switching from the internally oriented default mode network (DMN) to the externally oriented executive control network (CEN) (19)