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they note that it does, however, contribute to heart disease and that its linked with worse outcomes for patients already suffering from hypertension

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Cotinine and nicotine were reported to display equal efficacy in displacing [ 125 I]-bungarotoxin binding (presumably low-affinity 7 nAChRs), but cotinine was 100 fold less potent than nicotine, with IC 50 values at 1 mM and 10 M, respectively (Riah et al., 1999)

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Thus, our results support the hypothesis of smoking being a protective factor against PD