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Pre-publication history The pre-publication history for this paper can be accessed here: Acknowledgements Grateful thanks go to Pauline Wall and colleagues at the NHS-IC for issue of death registrations, and to Sam Wilkinson, Elaine Brown and Damien McElvenny for re-establishing the UK Cotton Workers Cohort

Expectancy of treatment will be assessed with a four-item Borkovec and Nau self-assessment credibility scale during and after intervention