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Effect of an electronic nicotine delivery device (e cigarette) on desire to smoke and withdrawal, user preferences and nicotine delivery: randomised cross-over trial

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Drug addiction including nicotine dependence is known as a disorder of altered brain function brought on by psychoactive substances use, and it is possible that such alterations may manifest as altered BEN, but this has not yet been assessed

Even if the smoke is not inhaled, high levels of nicotine (the chemical that causes the actual addiction) can still be absorbed into the body by inhalation into the lungs and by absorption through the lining of the oral cavity