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Interestingly, both ILC1 and ILC3 subsets expressed Sphingosine-1-phosphate receptor 1 (S1PR1), which explains their reduced absolute numbers in the peripheral blood of RRMS patients treated with Fingolimod, a sphingosine 1-phosphate receptor modulator used as a first-line therapy for RRMS, compared with treatment-free pwMS (187), suggesting that S1PR1 agonist sequesters peripheral blood human ILCs in lymph nodes

This is in keeping with their commitment to support a smoke-free future and promote public health

Additionally, future research should incorporate more granular assessments of national tobacco control policies and socio-cultural contexts to better contextualize behavioral findings and guide country-specific public health interventions

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