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typhimurium strains TA 98, TA 100, and TA 102.[] Occupational exposure to bidi tobacco was found to result in direct urinary mutagenicity in strain TA 98 and upon treatment with B glucuronidase among bidi rollers, while the samples from tobacco processors exhibited direct mutagenicity in strains TA98, TA100, and TA102.[] Toxic effects on cells: Treatment of Syrian golden hamster tracheal epithelial cell line (HTE) with a non-toxic dose of an aqueous extract of bidi tobacco induced cellular hypertrophy, widening of intercellular spaces, and stimulated ornithine decarboxylase activity and the rate of DNA synthesis

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