can cigarettes cause a sore throat on Fire: Smoking Throat? Smoking doesn't just affect your

E-cigarettes induce the production of pro-inflammatory mediators and proteases, damaging lung connective tissue and parenchymal cells, suppressing alveolar macrophage phagocytic and defensive capabilities, and further increasing susceptibility to respiratory infections [78]

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Historically, substance/alcohol use and tobacco dependence are treated separately

Chronic rhinosinusitis (CRS) is characterized by immune disorders and mucociliary dysfunction, and e-cigarette-induced nasal epithelial cell dysregulation may be a fundamental basis for CRS development [33]

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