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In addition, a group of metabolic enzymes for TTMA-associated polymorphisms on ADH1B, GSTM1, CYP2E1 and COMT can be involved in metabolic pathway for benzene (Figure 3B)

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The underlying mechanisms are complex, involving direct and indirect toxic effects, immunologic dysregulation, and oncogenic pathways, primarily driven by oxidative stress, systemic inflammation, insulin resistance, and the presence of numerous carcinogens in tobacco smoke

Safety This product may be hazardous to health and is intended for use by adult smokers and recreational nicotine consumers

Under 30