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Nicotine overdose, or nicotine poisoning, is a condition whose symptoms include muscle twitching, fainting, vomiting, heart palpitations, seizures and difficulty breathing

Interestingly, levels were significantly increased in PBECs from COPD patients when compared to non-smoking control PBECs, while a trend was visible when compared to PBECs from smokers, indicating a disease-related effect (Figure 5A)

Some people don't have symptoms, though

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In 2018, 1 in 5 American high school students reported using e-cigarettes

"With the number of young people using e-cigarettes spiking it is not only critical that there is research into nicotine addiction treatments for this population, but it is imperative that we continue efforts to prevent youth from ever using nicotine. But not everyone is in favor of an all-out ban on such products, suggesting that it may drive consumers back toward tobacco products