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Among them, nicotine is extensively used since it is an ingredient common to cigarettes and e-cigarettes with well-documented addiction promoting activity and toxicity [18, 27, 43]

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Routine chronic disease monitoring that requires no additional significant clinical decision-making isn't a "significant, separately identifiable E/M service" under the AMA definition

Iskandar AR, Gonzalez-Suarez I, Majeed S, Marescotti D, Sewer A, Xiang Y, Leroy P, Guedj E, Mathis C, Schaller J-P, Vanscheeuwijck P, Frentzel S, Martin F, Ivanov NV, Peitsch MC, Hoeng J (2016) A framework for in vitro systems toxicology assessment of e-liquids