chewing tobacco replacement therapy The effectiveness of nicotine on oral smokeless cessation and reduction rate: A systematic review Nicotine Replacement Therapy - an

Each cigarette contains 15 mg of tar and 1.0 mg of nicotine

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The carcinogenic chemicals in cigarettes damage DNA in oral tissues, leading to abnormal cell growth and, in severe cases, fatal outcomes

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[86] Nicotine is a parasympathomimetic stimulant [89] that binds to and activates nicotinic acetylcholine receptors in the brain, [90] which subsequently causes the release of dopamine and other neurotransmitters, such as norepinephrine, acetylcholine, serotonin, gamma-aminobutyric acid, glutamate, endorphins, [91] and several neuropeptides, including proopiomelanocortin-derived -MSH and adrenocorticotropic hormone

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