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[71] found that the expression of protein arginine methyltransferase 6 (PRMT6) and asymmetric di-methylation of histone H3 arginine 2 (H3R2me2a) were significantly decreased in the lung tissues of patients with COPD who continue to smoke and CSE-induced mice

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Smoking remains one of the leading preventable causes of disease and death worldwide, responsible for up to two-thirds of fatalities among long-term smokers

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