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[79] Although several studies have found lower levels of carcinogens in e-cigarette aerosol compared to smoke emitted by traditional cigarettes, the mainstream and second-hand e-cigarette aerosol has been found to contain at least ten chemicals that are on California's Proposition 65 list of chemicals known to cause cancer, birth defects, or other reproductive harm, including acetaldehyde, benzene, cadmium, formaldehyde, isoprene, lead, nickel, nicotine, N -Nitrosonornicotine, and toluene

Sensitivity analysis using AAPC showed values of -0.13 (95% CI: -0.23 -0.03) for East Asia and -0.03 (95% CI: -0.100.05) for Eastern Europe

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