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The Interactions between Smoking and Sleep 11 Ways to Relieve Insomnia When You Quit Smoking Does smoking make you tired? Effects on the lungs, heart, and more Smoking can have a significant impact on sleep quality and duration. Nicotine is a stimulant that can interfere with sleep by increasing heart rate, blood pressure, and brain activity. Smokers are Smoking doesn't clock out when you go to bed. Even hours after your last puff, nicotine continues to affect your brain, keeping you restless, wired, and far from real sleep. Poor sleep It may feel like smoking helps you stay awake after a sleepless night, but that false alertness comes from a surge of adrenaline, which triggers a racing pulse, inflammation, and nasty jitters
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