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Coveys study, 43 percent successfully quit using a combination of behavioral counseling and the nicotine patch (in most clinical trials of smoking cessation treatments, 20 percent to 30 percent of participants quit)

This indicates that the decrease in dynamic compliance is related to the severity of airflow limitation

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That report says: Some of the carcinogens, oxidants and other toxins present in tobacco smoke have also been detected in e-cigarette vapour, raising the possibility that long-term use of e-cigarettes may increase the risk of lung cancer, COPD, cardiovascular and other smoking-related diseases

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The refill contains e-liquid, which includes nicotine and other chemical ingredients that are vaporised for inhalation