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Juul and other brands of e-cigarettes do pose health risks including respiratory problems, chemical addiction, nicotine poisoning and other issues

[23] In 2024, the FDA cleared an investigational new drug (IND) application for a fast-acting inhalable NRT, which delivers nicotine without combustion or heating

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As none of these thresholds (neither human data nor animal data) was available for the illicit drugs, LD50 values from animal experiments were selected instead and extrapolated to BMDL

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