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Nicotine (2 ng/mL cutoff), three nicotine metabolites [cotinine (5 ng/mL cutoff), 3-OH-cotinine (50 ng/mL cutoff), nornicotine (2 ng/mL cutoff)], and the tobacco metabolite anabasine (3 ng/mL cutoff)] were measured using quantitative liquid chromatography-tandem mass spectrometry (ARUP Laboratories, Salt Lake City, UT) and adjusted for urinary creatinine (see17 for further details on methodology)

A recent study by the Institute for Global Tobacco Control revealed that within 200 m of schools, 90% of the 353 retailers surveyed sold flavored tobacco cigarettes [24]

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RYO cigarettes : As smokers can determine the amount of tobacco themselves, the nicotine content varies according to preference

As a result of those investigations, defendants knew that youth were highly susceptible to marketing and advertising appeals, would underestimate the health risks and effects of smoking, would overestimate their ability to stop smoking, and were price sensitive