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Ethics statement The studies involving human participants were reviewed and approved by Ethikkommission Universittsklinikum Essen

According to the WHO, tobacco causes more than 8 million deaths a year throughout the planet, in addition to being the main cause of diseases and other ailments that reduce the quality of life of those who smoke

Manufacturers of these products must submit a pre-market application to the FDA prior to marketing their products

The TMV treatment yielded an ELISA value of 2.02, whereas the mock treatment showed a value of 0.21

The causal mechanisms remain undefined

State Summary State It is illegal to sell, offer to sell, barter or give tobacco products to persons under 21 years of age