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As for the drug taking supporters, I'm afraid you're just sheep, a complete and utter irrelevance

To reduce the effect of bias, we adjusted observations that were generated in subpopulations, because it was the only significant bias covariate identified by the bias covariate selection algorithm (Supplementary Table 7)

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(3) Most studies considered time-independent confounders [6-9,11], such as measuring motivation to quit smoking only at baseline