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Extracts from tobacco rods were serially diluted and superfused over HEK293T cells expressing the human TRPM8 cold/menthol receptor activated by menthol, WS-3 and other synthetic cooling agents, measuring activity by Calcium-microfluorimetry as published (Supplementary file) 3

Yet another embodiment of the invention, wherein the smoke from activated charcoal filter of cigarettes, cigars, pipes, cigar holders or any other conventional smoking devices exhaled by smokers containing markedly low level of p-BSQ is potentially less hazardous to passive smokers