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The results also indicated that smokers tended to start with tobacco-flavored products, and then would switch to multiple flavors as they transitioned from dual use to complete (or nearly complete) substitution of e-cigarettes for their usual combustible tobacco cigarettes

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Age was a significant independent predictor of plasma cotinine levels in our data, but the regression of cotinine against cigarette frequency did not differ significantly by age as was reported in the smoking reduction trials (9)

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Disease prevention as social change: The state, society, and public health in the United States, France, Great Britain, and Canada (Russell Sage Foundation, 2007), pp 109-159 on tobacco online PerettiWatel, Patrick, et al