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1964 A report published by an advisory committee to the surgeon general recognizes a link between smoking and lung cancer

While IL-31RA antagonists such as nemolizumab have demonstrated clinical efficacy, emerging targets like MRGPRX2 and TRPV1/TRPA1 channels offer additional therapeutic avenues but face challenges in translation and safety

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Ann Intern Med 136:270279 Hersh CP, Dahl M, Ly NP, Berkey CS, Nordestgaard BG, Silverman EK (2004) Chronic obstructive pulmonary disease in alpha1-antitrypsin PI MZ heterozygotes: a meta-analysis

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