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In contrast to the S phase accumulation of AA5-treated cells, which begin to partially resolve around 48 h post-treatment, BRQ-induced S phase accumulation largely persisted up to 72 h, highlighting the distinction between BRQs full block of pyrimidine synthesis at DHODH versus a competitive inhibition of pyrimidine synthesis at ATCase by succinate, which may be overcome with sufficient aspartate accumulation

The outcome variable was the different pack selections (e.g

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Epidermal growth factor receptor signalling contributes to house dust mite-induced epithelial barrier dysfunction