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In a randomized, double-blind, placebo-controlled study topiramate has shown gender-specific effects, men were approximately four times more likely to quit smoking when treated with topiramate as compared to placebo [95]

58 The Journal of American Folklore , 78 (308): 99114, doi:10.2307/538277, JSTOR 538277 "Tools of the Trade, Tobacco smoke enemas", The Lancet , 359 (9315): 1442, doi:10.1016/S0140-6736(02)08339-3, S2CID 54371569, retrieved 2008-11-27 Provincial Medical & Surgical Journal , vol

Environmental exposures, along with lifestyle behaviors such as exercise, alcohol consumption, and medication use, also significantly affect microbiome composition [125,126,127]

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On the other hand, exclusive smokeless tobacco use among youth also contributes to the initiation of cigarette smoking and poly-tobacco use during adolescence and adulthood [25, 26], and increases the risk of tobacco-related chronic disease and mortality in adults [27]