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If someone has smoked for a long time, does it make any difference or is it just too late

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Elmer, "Review of Recent Court Cases Involving Cigarette Tax Statutes," in Proceedings from the 27 th Annual Meetings of the National Tobacco Tax Association (Chicago: Federation of Tax Administrators, 1953), 11

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Unsurprisingly, compared with mice exposed to clean air, mice that been exposed to the smoke showed significant inflammation in their lungs