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Historically, from the 1970s, the tobacco industry has conducted pharmacological studies on several nicotine analogs, to understand their pharmacological effects and determine their potential to replace nicotine in products and also to circumvent any foreseeable regulations on nicotine 14

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Innovative tobacco control policies, such as the single pack presentation in Uruguay, can also hamper the cigarette pack from being an effective marketing channel 32

The Flum Pebble was released near the end of 2022 with upgraded features that include a higher puff number, larger e-liquid volume, and a rechargeable battery