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Although the results of cohort and case-control studies differed markedly, a multiplicative interaction effect of heavy alcohol consumption and heavy smoking on cancer risk was observed in both cohort and case-control studies

[19] He also visited sites in Germany that are associated with the Reformation leader Martin Luther

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Stated thus, these studies suggested that alterations of gut microbiome may be an essential contributing factor to the initiation and development of this cancer in the context of smoking